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Transformer models have been widely investigated in different domains by providing long-range dependency handling and global contextual awareness, driving the development of popular AI applications such as ChatGPT, Gemini, and Alexa. State Space Models (SSMs) have emerged as strong contenders in the field of sequential modeling, challenging the dominance of Transformers. SSMs incorporate a selective mechanism that allows for dynamic parameter adjustment based on input data, enhancing their performance. However, this mechanism also comes with increasing computational complexity and bandwidth demands, posing challenges for deployment on resource-constraint mobile devices. To address these challenges without sacrificing the accuracy of the selective mechanism, we propose a sparse learning framework that integrates architecture-aware compiler optimizations. We introduce an end-to-end solution–C 4 n kernel sparsity, which prunes n elements from every four contiguous weights, and develop a compiler-based acceleration solution to ensure execution efficiency for this sparsity on mobile devices. Based on the kernel sparsity, our framework generates optimized sparse models targeting specific sparsity or latency requirements for various model sizes. We further leverage pruned weights to compensate for the remaining weights, enhancing downstream task performance. For practical hardware acceleration, we propose C 4 n -specific optimizations combined with a layout transformation elimination strategy. This approach mitigates inefficiencies arising from fine-grained pruning in linear layers and improves performance across other operations. Experimental results demonstrate that our method achieves superior task performance compared to other semi-structured pruning methods and achieves up-to 7→ speedup compared to llama.cpp framework on mobile devices. 

We present the first measurement of cosmic-ray fluxes of ${}^6\mathrm{Li}$and ${}^7\mathrm{Li}$isotopes in the rigidity range from 1.9 to 25 GV. The measurements are based on $9.7\times {10}^5$ ${}^6\mathrm{Li}$and $1.04\times {10}^6$ ${}^7\mathrm{Li}$nuclei collected by the Alpha Magnetic Spectrometer on the International Space Station from May 2011 to October 2023. We observe that over the entire rigidity range the ${}^6\mathrm{Li}$and ${}^7\mathrm{Li}$fluxes exhibit nearly identical time variations and, above $\sim 4\mathrm{GV}$, the time variations of ${}^6\mathrm{Li}$, ${}^7\mathrm{Li}$, He, Be, B, C, N, and O fluxes are identical. Above $\sim 7\mathrm{GV}$, we find an identical rigidity dependence of the ${}^6\mathrm{Li}$and ${}^7\mathrm{Li}$fluxes. This shows that they are both produced by collisions of heavier cosmic-ray nuclei with the interstellar medium and, in particular, excludes the existence of a sizable primary component in the ${}^7\mathrm{Li}$flux. Published by the American Physical Society2025 

We report the properties of precision time structures of cosmic nuclei He, Li, Be, B, C, N, and O fluxes over an 11-year solar cycle from May 2011 to November 2022 in the rigidity range from 1.92 to 60.3 GV. The nuclei fluxes show similar but not identical time variations with amplitudes decreasing with increasing rigidity. In particular, below 3.64 GV the Li, Be, and B fluxes, and below 2.15 GV the C, N, and O fluxes, are significantly less affected by solar modulation than the He flux. We observe that these differences in solar modulation are linearly correlated with the differences in the spectral indices of the cosmic nuclei fluxes. This shows, in a model-independent way, that solar modulation of galactic cosmic nuclei depends on their spectral shape. In addition, solar modulation differences due to nuclei velocity dependence on the mass-to-charge ratio ( $A/Z$) are not observed. Published by the American Physical Society2025 

The triboelectric energy generators prepared using the combination of self-polarized, high β-phase nanocomposite films of Gd5Si4-PVDF and polyamide-6 (PA-6) films have generated significantly higher voltage of ∼425 V, short-circuit current density of ∼30 mA/m2 and a charge density of ∼116.7 μC/m2 as compared to corresponding values of ∼300 V, 30 mA/m2 and 94.7 μC/m2, respectively for the pristine PVDF-(PA-6) combination. The magnetic measurements of the Gd5Si4-PVDF films display a ferromagnetic behavior as compared to diamagnetic nature of pristine PVDF. The presence of magnetic nanoparticles in the polymeric matrix allows for some control over the microstructural properties during the preparation process. The results open new routes for multiferroic composite films to be suitable for multi-functional magnetic and triboelectric energy harvesting applications. 

Precision measurements by the Alpha Magnetic Spectrometer (AMS) on the International Space Station of the deuteron ( $D$) flux are presented. The measurements are based on $21\times {10}^6$ $D$nuclei in the rigidity range from 1.9 to 21 GV collected from May 2011 to April 2021. We observe that over the entire rigidity range the $D$flux exhibits nearly identical time variations with the $p$, ${}^3\mathrm{He}$, and ${}^4\mathrm{He}$fluxes. Above 4.5 GV, the $D/{}^4\mathrm{He}$flux ratio is time independent and its rigidity dependence is well described by a single power law $\propto R^{\mathrm{\Delta }}$with ${\mathrm{\Delta }}_{D/{}^4\mathrm{He}}=-0.108\pm 0.005$. This is in contrast with the ${}^3\mathrm{He}/{}^4\mathrm{He}$flux ratio for which we find ${\mathrm{\Delta }}_{{}^3\mathrm{He}/{}^4\mathrm{He}}=-0.289\pm 0.003$. Above $\sim 13\mathrm{GV}$we find a nearly identical rigidity dependence of the $D$and $p$fluxes with a $D/p$flux ratio of $0.027\pm 0.001$. These unexpected observations indicate that cosmic deuterons have a sizable primarylike component. With a method independent of cosmic ray propagation, we obtain the primary component of the $D$flux equal to $9.4\pm 0.5\%$of the ${}^4\mathrm{He}$flux and the secondary component of the $D$flux equal to $58\pm 5\%$of the ${}^3\mathrm{He}$flux. Published by the American Physical Society2024 

Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals. 

Abstract A search for leptoquark pair production decaying into$$te^- \bar{t}e^+$$ $t{e}^{-}\overline{t}{e}^{+}$or$$t\mu ^- \bar{t}\mu ^+$$ $t{\mu }^{-}\overline{t}{\mu }^{+}$in final states with multiple leptons is presented. The search is based on a dataset ofppcollisions at$$\sqrt{s}=13~\text {TeV} $$ $\sqrt{s}=13\text{TeV}$recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb$$^{-1}$$ $_{}^{-1}$. Four signal regions, with the requirement of at least three light leptons (electron or muon) and at least two jets out of which at least one jet is identified as coming from ab-hadron, are considered based on the number of leptons of a given flavour. The main background processes are estimated using dedicated control regions in a simultaneous fit with the signal regions to data. No excess above the Standard Model background prediction is observed and 95% confidence level limits on the production cross section times branching ratio are derived as a function of the leptoquark mass. Under the assumption of exclusive decays into$$te^{-}$$ $t{e}^{-}$($$t\mu ^{-}$$ $t{\mu }^{-}$), the corresponding lower limit on the scalar mixed-generation leptoquark mass$$m_{\textrm{LQ}_{\textrm{mix}}^{\textrm{d}}}$$ $m_{{\text{LQ}}_{\text{mix}}^{\text{d}}}$is at 1.58 (1.59) TeV and on the vector leptoquark mass$$m_{{\tilde{U}}_1}$$ $m_{{\tilde{U}}_1}$at 1.67 (1.67) TeV in the minimal coupling scenario and at 1.95 (1.95) TeV in the Yang–Mills scenario.